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Contrived Tears with Histamine

Contrived Tears with Histamine (artificial tears) for your every need.

Our Contrived Tears with Histamine have been developed from > 15 components known to be present in tears, balancing protein, salt and pH alike, in line with accepted tear formulations and tear histamine levels. [1-7] Our Contrived Tears with Histamine are a low cost solution to your diagnostic testing, instrument calibration and research needs and are sold in 5, 10 and 20 ml volumes. The tear osmolarity of our normal healthy subject tears is 300 mOsms/L with a pH of 7.4 and a histamine concentration of 2 ng/ml.

Our Contrived Tears with Histamine Kit (artificial tears), features 6 vials with differing histamine levels. Our Contrived Tears with Histamine have been developed from > 15 components known to be present in tears, balancing protein, salt and pH alike, in line with accepted tear formulations and histamine levels reported in the peer reviewed literature. Our Contrived Tears with Histamine Kit offers the same tear formulation as our Standard Tears (osmolarity - 300 mOsms/L), but with varying Histamine levels, reflecting both normal subject,  2 ng/ml Histamine,  as well as higher levels of Histamine known to be present [1-7], 5, 10, 15, 25 and 50 ng/ml during allergic and non-allergic (associated with infection) conjunctivitis. Our Contrived Tears with Histamine are a low cost solution to your diagnostic and research needs and are sold in 1 ml pre-made volumes of 2, 5, 10, 15, 25 and 50 ng/ml Histamine, with a tearosmolarity of 300 mOsms/L salt / protein, at pH 7.4. Larger tear volumes are available on special request to This email address is being protected from spambots. You need JavaScript enabled to view it. .

All Ursa BioScience™ tear products are intended for research use only and are not intended for human or animal use.

 

Cited References

[1] H. Fujishima, I. Saito, T. Takeuchi, N. Shinozaki, and K. Tsubota, 'Measurement of Interleukin-4 and Histamine in Superficial Cells of Conjunctiva in Patients with Allergic Conjunctivitis', Current Eye Research, 15 (1996), 209-13.

[2] M. T. Irkec, and B. Bozkurt, 'Molecular Immunology of Allergic Conjunctivitis', Current Opinion in Allergy and Clinical Immunology, 12 (2012), 534-39.

[3] A. Leonardi, 'Allergy and Allergic Mediators in Tears', Experimental Eye Research, 117 (2013), 106-17.

[4] E. M. M. Mourao, N. A. Rosario, L. Silva, and S. E. Shimakura, 'Ocular Symptoms in Nonspecific Conjunctival Hyperreactivity', Annals of Allergy Asthma & Immunology, 107 (2011), 29-34.

[5] M. Ohbayashi, B. Manzouri, K. Morohoshi, K. Fukuda, and S. J. Ono, 'The Role of Histamine in Ocular Allergy', in Histamine in Innflammation, ed. by R. L. Thurmond (Berlin: Springer-Verlag Berlin, 2010), pp. 43-52.

[6] H. G. Struck, A. Wicht, K. Ponicke, C. Lautenschlager, and D. Lubbe, 'Histamine Content in Tears in Patients with Allergic Rhinoconjunctivitis', Ophthalmologe, 95 (1998), 241-46.

[7] I. Venza, M. Visalli, G. Ceci, and D. Teti, 'Quantitative Determination of Histamine in Tears During Conjunctivitis by a Novel Hplc Method', Ophthalmic Research, 36 (2004), 62-69.

 

 

 

We offer Tear Analytical  Services, such as Viscosity and  Osmolarity determination for your samples.

histamine