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Contrived Tears with Adenovirus

Ursa BioScience will soon offer Contrived Tears with Adenovirus in 1 and 5 ml vials for researchers and diagnostic applications alike. Containing complete but dead viral material, our tears are ideal for PCR and immunoassay testing / calibration applications.

All Ursa BioScience™ tear products are intended for research use only and are not intended for human or animal use.

Ocular Infections

Adenoviruses present a serious public health risk and are responsible for 65-90 % of viral conjunctivitis and 15-70 % of all cases of infectious conjunctivitis worldwide. [1] Unlike many bacterial pathogens, such as Staphylococcus aureus and Staphylococcus epidermidis, which are often part of the normal ocular flora, [2] the presence of adenovirus by culture is indicative of active infection.[3]

Adenoviruses are non-enveloped, double-stranded-DNA viruses with icosahedral capsids. [4] Of the seven species (A to G), Species D overwhelmingly causes conjunctivitis, [5, 6] with species E found in both respiratory and ocular infections, but more commonly in conjunctivitis. [5]

Adenoviral ocular infections are classified into four distinct syndromes: pharyngoconjunctival fever (PCF); epidemic keratoconjunctivitis (EKC); acute nonspecific follicular conjunctivitis (NCF) and chronic keratoconjunctivitis. Of the four distinct syndromes, EKC is the most serious form of ocular adenoviral infection and is usually associated with serotypes 8 and 19. EKC is readily transmitted via close personal contact as well as during non-sterile eye examinations with contaminated ophthalmic instruments. [7] After an eight-day incubation period, tears and saliva are contagious for about two weeks. The conjunctivitis almost always is resolved within a 2-3 week window.

Cited References

[1] Maranhao, A.G., et al., Molecular epidemiology of adenovirus conjunctivitis in rio de janeiro, brazil, between 2004 and 2007. Revista Do Instituto De Medicina Tropical De Sao Paulo, 2009. 51(4): p. 227-229.

[2] Abelson, M.B. and M.R. Allansmith, Normal conjunctival wound edge flora of patients undergoing uncomplicated cataract extraction. Am J Ophthalmol., 1973. 76(4): p. 561-5.

[3] Gigliotti, F., et al., Etiology of acute conjunctivitis in children. J Pediatr, 1981. 98(4): p. 531-6.

[4] Swenson PD, W.G., Allard A, Hierholzer JC. Adenoviruses. In: Manual of Clinical Microbiology, 8 ed, vol 2. Washington, D.C.: ASM Press, 2003.

[5] Chang, S.Y., et al., A community-derived outbreak of adenovirus type 3 in children in Taiwan between 2004 and 2005. Journal of Medical Virology, 2008. 80(1): p. 102-112.

[6] Sambursky, R.P., N. Fram, and E.J. Cohen, The prevalence of adenoviral conjunctivitis at the Wills Eye Hospital Emergency Room. Optometry, 2007. 78(5): p. 236-9.

[7] Tullo, A.B., Shipyard eye. Br Med J (Clin Res Ed), 1981. 283(6298): p. 1056-7.


 We offer Tear Analytical  Services, such as Viscosity and  Osmolarity determination for your samples.